History of DMSO: From Industry to Medicine

The History of DMSO: From Wood Pulp to Controversy

DMSO’s story begins in the 19th century, when Russian chemist Alexander Saytzeff first isolated it from wood pulp in 1866. At the time, it was just another industrial solvent — useful in manufacturing, but not much more.

Fast forward to the mid-20th century, and researchers noticed something unusual: DMSO wasn’t just dissolving compounds, it was also penetrating the skin and carrying those compounds deep into tissues and cells. This discovery turned an industrial chemical into a potential medical breakthrough.

In the 1960s, DMSO burst onto the scientific scene with bold claims. Early studies suggested it could reduce inflammation, relieve pain, and even protect cells from damage. Word spread quickly, and excitement built around its possibilities for treating arthritis, sports injuries, and skin conditions.

But with hype came controversy. The U.S. FDA stepped in, concerned about safety and the lack of large-scale clinical trials. By the late 1960s, DMSO was restricted for human use, except in a few specific medical cases such as treating interstitial cystitis (a painful bladder condition).

Despite this, DMSO never disappeared. It became a staple in veterinary medicine, especially for horses with joint and muscle injuries, and scientists kept studying it for cancer, inflammation, and drug delivery. Today, DMSO remains one of those rare substances that sits in the space between industrial chemical, medical tool, and underground remedy.

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