DMSO and Inflammation: The Science, Benefits, and Risks Explained

DMSO and Inflammation: The Science, Benefits, and Risks Explained

Inflammation is at the root of many modern health conditions — from aching joints to sports injuries and even chronic disease. While short-term inflammation is part of the body’s natural healing process, long-term or excessive inflammation can create pain, stiffness, and tissue damage.

This is where DMSO (dimethyl sulfoxide) enters the conversation. Known for its powerful anti-inflammatory and antioxidant properties, DMSO has been studied for decades as both a medical tool and an alternative therapy. But what does the science really say about DMSO and inflammation? And is it something worth considering for pain and healing?

Let’s break it down.

What is DMSO?

DMSO, or dimethyl sulfoxide, is an organic compound originally derived from wood pulp. What makes it unique is its remarkable ability to:

• Penetrate skin and cell membranes rapidly.

• Carry other compounds with it into the body (making it a powerful drug delivery vehicle).

• Reduce inflammation and oxidative stress at a cellular level.

Because of these properties, DMSO has been explored for everything from arthritis relief to wound healing. It’s even approved in certain countries for medical use, though its status varies depending on the region.

👉 For a full overview, read our guide: What is DMSO and How Does It Work?

The Science: How DMSO Impacts Inflammation

Inflammation is driven by molecules in the body called free radicals and cytokines. These act like sparks and fire alarms, signaling tissues to swell, heat up, and sometimes become painful.

Here’s how DMSO interacts with the process:

1. Antioxidant effect – DMSO neutralizes free radicals, reducing oxidative stress.

2. Cell membrane support – It helps stabilize cell walls, protecting tissues from further damage.

3. Improved blood flow – By reducing clot formation and enhancing circulation, DMSO may support the delivery of oxygen and nutrients to inflamed areas.

4. Pain modulation – Some studies suggest DMSO alters nerve conduction, which could explain its pain-relieving qualities.

📌 A 2016 review in Inflammopharmacology found that DMSO demonstrated both anti-inflammatory and analgesic effects, especially in joint and connective tissue conditions.

Benefits of DMSO for Inflammatory Conditions

People exploring DMSO often fall into one of two groups: those with chronic inflammatory conditions and those dealing with acute injuries.

1. Arthritis and Joint Pain

Research shows DMSO may reduce swelling, stiffness, and pain in arthritis patients by calming inflammation inside the joints. Some clinical trials compared it to NSAIDs (like ibuprofen) with promising, though mixed, results.

👉 Related post: DMSO and Arthritis: What the Research Really Says

Risks and Safety Considerations

While DMSO shows promise, it isn’t risk-free. Safety depends on purity, dosage, and method of use.

Possible side effects include:

• Skin irritation (itching, redness, or rash).

• Garlic-like breath or body odor.

• Headaches or dizziness (especially at high concentrations).

• Interactions with medications — because DMSO carries other compounds into the body, unsafe pairings can be risky.

📌 Important: Only pharmaceutical-grade DMSO should ever be considered. Industrial solvents are unsafe for human use.

👉 For more, read: The Risks of DMSO: Side Effects, Myths, and What Science Says

What the Experts Say

While some clinicians remain cautious due to limited regulatory approval, research interest continues. Studies highlight DMSO’s potential as both an anti-inflammatory therapy and a carrier for other medications.

• The Journal of Pain Research (2018) noted that DMSO’s ability to reduce swelling made it a strong candidate for joint pain relief.

• Veterinary medicine has long used DMSO safely for horses and pets with inflammatory injuries.

👉 See: DMSO in Veterinary Medicine: A Comprehensive Guide

The Future of DMSO and Inflammation

Looking ahead, researchers are particularly excited about DMSO as part of drug delivery systems. Instead of acting as a cure on its own, DMSO may enhance existing treatments by helping them penetrate tissues more effectively.

This could mean more targeted anti-inflammatory therapies with fewer side effects.

Key Takeaways

• DMSO is a powerful anti-inflammatory compound, with decades of research behind it.

• It may help with arthritis, injuries, wound healing, and other inflammation-driven issues.

• Risks exist — especially if non-medical grade products are used.

• The future likely lies in combining DMSO with other therapies, not using it as a standalone cure.

Recommended Next Reads:

• DMSO and Arthritis: What the Research Really Says
• The Risks of DMSO: Side Effects, Myths, and What Science Says
• How to Use DMSO Safely: Applications and Guidelines
• How to Use DMSO Safely: Applications and Guidelines